In his LRF research, Dr. Russler-Germain aims to study how mutations in a gene known as ZNF608 may contribute to the formation of lymphoma. “From our preliminary understanding of ZNF608, we hypothesize it plays a key role in protecting B cells from inappropriate activation of the machinery normally used by immune cells to alter their DNA in response to infections,” he explains. “Loss of ZNF608 may promote acquisition of mutations and lead to accelerated development of lymphoma.”
David Russler-Germain, MD, PhD, Receives 2 Fellowship Awards
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